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Development of Diagnostic Assays for Rapid Detection of Antibiotic Resistance

INTRODUCTION: 
Antibiotic resistant bacteria are a rising public health threat . Antibiotic resistant bacteria cause complication of therapy of other diseases in many clinical branches (e.g., cardiology/cardiosurgery, intensive medicine, transplantology).

TECHNOLOGY (INVENTION) DESCRIPTION: 
Development of Rapid Assays for Detection of Resistance Mechanisms based on MALDI-TOF MS

ADVANTAGES OVER EXISTING SOLUTIONS: 
We developed a kit for functional detection of carbapenemases (the most danger resistance currently). All the assays are validated on our robust collection of resistant bacterial isolates (>1000)

DEVELOPMENT STATUS (STAGE): 
We developed and patented an assay for detection of enzymes responsible for degradation of common antibiotics(β-lactams)

PUBLICATIONS: 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553667/

IP PROTECTION STATUS: 
International Patent Application published under PCT on December 24, 2014

TECHNOLOGY / IP OWNERS : 
Charles University